Комплексная характеристика современных синтетических ирригационных растворов корневых каналов зубов

Бекжанова О.Е., Фуркатова С.Ф.

doi:10.57231/j.idmfs.2026.5.2.030

Complex characteristics of modern synthetic irrigation solutions for root canals of teeth

Authors

Бекжанова О.Е., Фуркатова С.Ф.

DOI:

https://doi.org/10.57231/j.idmfs.2026.5.2.030

Abstract

This article presents an analysis of modern synthetic irrigation solutions used in endodontics, evaluating their antimicrobial, tissue-dissolving, and chelating properties. The mechanisms of action of sodium hypochlorite, ethylenediaminetetraacetic acid, and chlorhexidine are considered, as well as their effect on root canal biofilm. Special attention is given to combined irrigation systems and their advantages over traditional solutions. The main disadvantages of currently used agents and the prospects for developing new preparations are also discussed.

References

Anu Priya Guruswamy Pandian, Deepti Bellani, Rithya Mary Jibu, Varsha Agnihotri, Endodontic intracanal drugs and agents , Dental Clinics of North America , 10.1016/j.cden.2025.07.005 , 70 , 1 , (45-62) , (2026)

Ballal, N.V., Jain, H., Rao, S., Johnson, A.D., Baeten, J., Walcott, J.F. Evaluation of the efficacy of SmearOFF, maleic acid, and two EDTA preparations in removing the smear layer from root canal dentin. Acta Odontol Scand. 2019;77(1):28–32.

Bhattacharya, Swastika; Purayil, Tina Puthen; Ballal, Nidambur Vasudev; Pentapati, Kalyana Chakravarty 1. Study of endodontic irrigant Irritrol™ and ethylenediaminetetraacetic acid on removal of smear layer from root canals of human dentin after instrumentation. Saudi Journal of Endodontics 10(2): pp. 106-110, May–August 2020 | DOI: 10.4103/sej.sej_94_19.

Boutsioukis K, Arias-Molise MT. Current status and future directions - irrigation and irrigation techniques. Int Endod J 2022;55(Suppl 3):588–612;

Busanello FH, Petridis X, So MV, Dijkstra RJ, Sharma PK, van der Sluis LW. Chemical biofilm removal capacity of endodontic irrigants as a function of biofilm structure:optical coherence tomography, confocal microscopy and viscoelasticity determination as integrated assessment tools. International Endodontic Journal. 2019 Apr;52(4):461-74.

Cai S, Chen S, Li Y, et al. Advances in the role of sodium hypochlorite irrigant solution in chemical root canal preparation. Biomed Res Int 2023;2023:8858283;

Çakır, A., Şahin, T. N., and Kahveci, O. Evaluation of the Efficiency of Different Irrigation Solutions in Dissolving Organic Tissues. Sci Rep 14 , 13861 (2024). https://doi.org/10.1038/s41598-024-64904-w

Çiçek, E.; Keskin, O. Effect of Temperature Variation of EDTA and MTAD on Smear Layer Removal: A Scanning Electron Microscopy Study. Scanning 2015 , 37 , 193–196

Dioguardi M, Di Gioia G, Illuzzi G, Laneve E, Cocco A, Troiano G. Endodontic irrigants: Different methods to improve efficacy and related problems. European journal of dentistry. 2018 Jul;12(03):459-66.

Fang, J.; Shen, Z.; van der Hoeven, R.; Jaramillo, D.E. Dissolution of bovine palatal tissue with degassed sodium hypochlorite. Dent. J. 2025, 13, 110. https://doi.org/10.3390/dj13030110

Foroughi, M.; Abolmaali, S.; Abedi, H.; Ravenel, T. Improving endodontic treatment outcomes with the synergistic microbicidal and activated root cleaning technique (SMART): a new approach in root canal irrigation. Medicina 2025 , 61 , 874.

Gazzaneo I, Vieira GC, Pérez AR, Alves FR, Gonçalves LS, Mdala I, Siqueira Jr JF, Rôças IN. Root canal disinfection by single-and multiple-instrument systems: effects of sodium hypochlorite volume, concentration, and retention time. Journal of endodontics.2019 Jun 1; 45(6):736-41.

Gomez-Delgado M, Camps-Font O, Luz L, Sanz D, Mercade M. An update on the use of citric acid in endodontic treatment: a systematic review. Odontology. 2023;111(1):1–19.

Kale PP, Raut AW. A proposed classification system for herbal endodontic irrigants. J Conserv Dent. 2021 May-Jun;24(3):293-295. doi: 10.4103/jcd.jcd_75_21. Epub 2021 Dec 8. PMID: 35035157; PMCID: PMC8717852.

Kapoor T, Matias EG, Gupta S, et al. Maleic acid as a root canal irrigant—a literature review. BMC Oral Health 26 , 76 (2026). https://doi.org/10.1186/s12903-025-07361-9

Kasidid Ruksakiet, Lilla Hanák, Nelli Farkas, Péter Hegyi, Wuttapon Sadaeng, László Márk Czumbel, Thanyaporn Sang-ngoen, András Garami, Alexandra Mikó, Gábor Varga, Zsolt Lohinai, Antimicrobial Efficacy of Chlorhexidine and Sodium Hypochlorite in Root Canal Disinfection: A Systematic Review and Meta-analysis of Randomized Controlled Trials // , Journal of Endodontics. – 2020.- Volume 46, Issue 8.- Pages 1032-1041.e7, ISSN 0099-2399, https://doi.org/10.1016/j.joen.2020.05.002. (https://www.sciencedirect.com/science/article/pii/S0099239920303083)

Kumar S, Sanjeev K, Sundaramoorthy N, Mahalaxmi S. Effect of gallic acid as a final irrigant on push-out bond strength of an epoxy resin sealer to root canal dentin. J Herbmed Pharmacol. 2023;12(4):500-504. doi: 10.34172/ jhp.2023.44919.

Liu H, Shen Y, Haapasalo M. Effectiveness of Six Irrigation Techniques With Sodium Hypochlorite in Tissue Dissolution. Cureus. 2023 May 18;15(5):e39208. doi: 10.7759/cureus.39208. PMID: 37337496; PMCID: PMC10276890

Mallick T, Ballal NV. Effect of glycolic acid, maleic acid, and EDTA on smear layer removal from root canal dentin. Pesqui Bras. 2023;23:e220058

Minati Jain et.al. A review on endodontic irrigants: herbal versus conventional // International Journal of Health Sciences and Research (www.ijhsr.org) 115 Volume 14; Issue: 11; November 2024 Р. 107-116

Mukundan, D.; Jeevanandan, G. Cytotoxic effect of two different concentrations of sodium hypochlorite: an in vitro study. Cureus 2024 , 16 , e66999

Orozco-Gallego MJ, Pineda-Velez EL, Rojas-Gutierrez VJ, Rincon-Rodriguez ML, Agudelo-Suarez AA. Efficiency of irrigation protocols in endodontic treatment: a review article. Dent J (Basel). 2025 Jun 18;13(6):273. doi: 10.3390/dj13060273.PMID: 40559176

Orozco-Gallego, M.J.; Pineda-Velez, E.L.; Rojas-Gutierrez, W.J.; Rincon-Rodriguez, M.L.; Agudelo-Suarez, A.A. Efficacy of irrigation protocols in endodontic therapy: an overview. Dent. J. 2025, 13, 273.

Palazzi, F.; Del Fabbro, M.; Taskieri, F.; Mohammadi, Z.; Asgari, S.; Boukiet, F. Comparison of the antimicrobial activity of six root canal irrigating solutions against Enterococcus faecalis . Iranian Journal of Endodontics. 2018, 13, 446–452

Ruiz‐Linares M, Aguado‐Pérez B, Baca P, Arias‐Moliz MT, Ferrer‐Luque CM. Efficacy of antimicrobial solutions against polymicrobial root canal biofilm. International endodontic journal. 2017 Jan;50(1):77-83.

Ruksakiet K, Hanak L, Farkas N, et al. Antimicrobial efficacy of chlorhexidine and sodium hypochlorite in root canal disinfection: a systematic review and meta-analysis of randomized controlled trials. J Endod 2020;46(8):1032–1041.e7;

Ruksakiet, Kasidid, et al. Antimicrobial efficacy of chlorhexidine and sodium hypochlorite in root canal disinfection: a systematic review and meta-analysis of randomized controlled trials// Journal of Endodontics, - 2020.- Volume 46, Issue 8, 1032-1041.e7

Senna R.А. ,¢ Spohr A. R. . Andressa Heberle Gastmann, DDS Fernanda Geraldo Pappen, PhD ¢ Regina Karla de Pontes Lima, PhD ¢ Renata Dornelles Morgental The effect of EDTA on the antibacterial activity of sodium hypochlorite // GENERAL DENTISTRY January/February 2018.- С.74 – 78.

SeveringAL, RembeJD, KoesterV, StuermerEK. Safety and efficacy profiles of various commercial sodium hypochlorite/chlorous acid (NaClO/HClO) solutions: antimicrobial efficacy, cytotoxic effects, and physicochemical parameters in vitro . J Antimicrob Chemother ( 2019 ) 74 : 365–372 10.1093 /jac/dky432

Sieminska, A.; Kot, K.; Marek, E.; Chamarchuk, A.; Kaczala, M.; Raslawska-Socha, J.; Schuster, L.; Dammaschke, T.; Szyszka-Sommerfeld, L.; Lipski, M. In vitro evaluation of the antimicrobial activity of endodontic irrigants containing disodium edetate and chlorhexidine gluconate, octenidine dihydrochloride, and benzalkonium bromide against intracanal Enterococcus faecalis . J. Clin. Med. 2025 , 14 , 7100. https://doi.org/10.3390/jcm14197100

Swimberghe RC, Coenye T, De Moor RJ, Meire MA. Biofilm model systems for root canal disinfection: a literature review. International Endodontic Journal. 2019 May;52(5):604-28.

Valsan, S., & Antony, S. D. P. (2022). Interaction of endodontic irrigants: A review // International Journal of Health Sciences,.- 2022.- 6(S2), 4282–4294. https://doi.org/10.53730/ijhs.v6nS2.5968

Wu, B.; Zhou, Z.; Hong, S.; Xu, Z.; Xu, Y.; He, Y.; Chen, S. Novel approaches to root canal disinfection methods against E. faecalis . J. Oral Microbiology. 2025, 17, 2475947.

Zarean, P.; Goellner, M.; Zarean, P.; Neuhaus, K.W. 2D and 3D erosion landscape analysis of endodontically treated teeth using EDTA and HEDP as chelating agents: a high-resolution micro-computed tomography study. Dent. J. 2023 , 11 , 286. https://doi.org/10.3390/dj11120286